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Aim: Cardiac basal metabolism upon extracellular calcium removal and its relationship with intracellular sodium and calcium homeostasis was evaluated.
Methods: A mechano‐calorimetric technique was used that allowed the simultaneous and continuous measurement of both heat rate and resting pressure in arterially perfused quiescent adult rat hearts. Using pharmacological tools, the possible underlying...
The energetic effect of extracellular Na+ removal and readmission (in a nominally Ca2+-free perfusate) in Langendorff-perfused ventricles of transgenic mice (TM), which overexpress the sarcolemmal Na+–Ca2+ exchanger; normal mice (NM); young (7–12 days old) rats (YR); and older (13–20 days old) rats (OR) was studied. In all heart muscles, extracellular Na+ removal induced an increase in heat production...
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