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Exercise is a common component of weight loss strategies, yet exercise programs are associated with surprisingly small changes in body weight [1–4]. This may be due in part to compensatory adaptations, in which calories expended during exercise are counteracted by decreases in other aspects of energy expenditure [1, 5–10]. Here we examined the relationship between a rodent model of voluntary exercise—...
Diet affects both lifespan and reproduction [1–9], leading to the prediction that the contrasting reproductive strategies of the sexes should result in sex-specific effects of nutrition on fitness and longevity [6, 10] and favor different patterns of nutrient intake in males and females. However, males and females share most of their genome and intralocus sexual conflict may prevent sex-specific diet...
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