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ST3 is a matrix metalloproteinase overexpressed in stromal fibroblasts at the tumour-stromal interface of invasive breast cancers (Basset et al, Nature, 1990; 348: 699-704) and levels of expression of its mRNA have been correlated with both degree of invasion of primary breast cancers and clinical outcome (Engel et al, International Journal of Cancer, 1994, 58 (6): 830-835). We have shown, in transient...
Brachial plexopathy (BP) is a significant cause of pain and disability in breast cancer patients. The anatomy of the plexus and its proximity to blood and lymphatic vessels makes this a difficult area to image accurately. 18-Fluoro-2-deoxyglucose (18-FDG) Positron Emission Tomography (PET) has previously been used to image primary and metastatic breast cancer (Wahl et al (1991). radiology, 179,...
ST3 is a matrix metalloproteinase specifically expressed in fibroblasts surrounding invasive foci of human breast cancers (Basset et al, Nature 1990; (348) 699-704). 0.46 kB (ST3-1) and 3.4 kB (ST3-2) of the 5'flanking sequence of the human ST3 gene were subcloned into expressionless chloramphenicol-acetyl transferase (CAT) and luciferase reporter vectors (pBLCAT6 and pGL3Basic respectively) for...
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