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BackgroundPeriostin is a matricellular protein, and its synthesis in airway epithelial cells and lung fibroblasts is induced by interleukin (IL)‐4 and IL‐13. The significance of periostin as a biomarker of TH2‐induced airway inflammation, and (importantly) as a measure of the response to TH2‐targeted therapy, has recently been emphasized. We explored the relationship between periostin and airway hyperresponsiveness...
BackgroundSoutheast Asian populations are increasingly affected by allergic airway diseases. Etiology and specific causes, however, are still unknown. The aim of this study is therefore to identify allergens and risk factors for the high prevalence of allergic airway disease in the tropical urban environment.
MethodsSymptoms of allergic rhinitis (AR), asthma, and allergic dermatitis were recorded...
BackgroundVascular endothelial growth factor (VEGF) plays a pro‐inflammatory mediator as well as a vascular permeability factor in bronchial asthma. Insulin‐like growth factor (IGF)‐I is also involved in the inflammatory process associated with bronchial asthma and stimulates VEGF expression. The IGF‐binding proteins (IGFBPs), especially IGFBP‐3, display distinctive properties and can interfere with...
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