Wyniki wyszukiwania dla: S. Haider

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Conformational flexibility of β‐arrestins – How these scaffolding proteins guide and transform the functionality of GPCRs

Raphael S. Haider, Mona Reichel, Edda S. F. Matthees, Carsten Hoffmann

BioEssays > 45 > 8 > n/a - n/a

G protein‐coupled receptors (GPCRs) constitute the largest family of transmembrane proteins and play a crucial role in regulating diverse cellular functions. They transmit their signaling via binding to intracellular signal transducers and effectors, such as G proteins, GPCR kinases, and β‐arrestins. To influence specific GPCR signaling behaviors, β‐arrestins recruit effectors to form larger signaling...

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Assessment of proline function in higher plants under extreme temperatures

A. Raza, S. Charagh, S. Abbas, M. U. Hassan, więcej

Plant Biology > 25 > 3 > 379 - 395

Climate change and abiotic stress factors are key players in crop losses worldwide. Among which, extreme temperatures (heat and cold) disturb plant growth and development, reduce productivity and, in severe cases, lead to plant death. Plants have developed numerous strategies to mitigate the detrimental impact of temperature stress. Exposure to stress leads to the accumulation of various metabolites,...

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Feasibility of virtual reality‐delivered pain psychology therapy for cancer‐related neuropathic pain: a pilot randomised controlled trial

A. Chuan, M. Hatty, M. Shelley, A. Lan, więcej

Anaesthesia > 78 > 4 > 449 - 457

Virtual reality‐delivered psychological therapies have recently been investigated as non‐pharmacological management for acute and chronic pain. However, no virtual reality pain therapy software existed that met the needs of cancer patients with neuropathic pain. We created a bespoke virtual reality‐delivered pain therapy software programme to help cancer patients manage neuropathic pain incorporating...

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Modelling trajectories of parentally reported and physician‐confirmed atopic dermatitis in a birth cohort study*

T. Nakamura, S. Haider, S. Fontanella, C.S. Murray, więcej

British Journal of Dermatology > 186 > 2 > 274 - 284

Background In a population‐based birth cohort, we aimed to identify longitudinal trajectories of atopic dermatitis (AD) during childhood using data from different sources (validated questionnaires and healthcare records). We investigated the impact of different AD definitions on such trajectories and their relationships with various risk factors. Methods Of the 1184 children born into the study,...

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Comprehensive RNA‐seq analysis revealed molecular pathways and genes associated with drought tolerance in wild soybean (Glycine soja Sieb. and Zucc.)

Muqadas Aleem, Muhammad M. Raza, Muhammad S. Haider, Rana M. Atif, więcej

Physiologia Plantarum > 172 > 2 > 707 - 732

Drought stress at the germination stage is an important environmental stress limiting crop yield. Hence, our study investigated comparative root transcriptome profiles of four contrasting soybean genotypes viz., drought‐tolerant (PI342618B/DTP and A214/DTL) and drought‐sensitive (NN86‐4/DSP and A195/DSL) under drought stress using RNA‐Seq approach. A total of 4850 and 6272 differentially expressed...

artykuł

Impact of different definitions of atopic dermatitis

T. Nakamura, S. Haider, S. Colicino, C.S. Murray, więcej

British Journal of Dermatology > 181 > 6 > e151 - e151

Atopic dermatitis (AD) is one of the most common skin diseases, but there is no single term used to define this illness. Although AD is currently the most commonly used name for this condition, other names (such as eczema) are also common. This may make it difficult to compare the results between studies and to understand the true burden of the disease. We found that researchers in different countries...

artykuł

不同特应性皮炎定义的影响

T. Nakamura, S. Haider, S. Colicino, C.S. Murray, więcej

British Journal of Dermatology > 181 > 6 > e163 - e163

特应性皮炎(AD)是最常见的皮肤病之一, 但没有单一术语来定义此病。尽管 AD 是此病目前最常使用的名称,其他名称(如湿疹)也常用。这可能导致难以比较不同研究之间的结果和了解真实的疾病负担。我们发现, 不同国家和不同医学专业的研究者们使用不同的名称(AD 或湿疹), 但这两个名称并不始终涉及相同的疾病。我们之后调查了在他们的研究中, 如果研究人员使用相同的名称 (AD), 但以略微不同的方式定义,是否会得到不同的结果和不同的结论。为此, 我们首先回顾了医学文献, 以找出研究人员定义 AD 的最常见方式。我们在回顾的 45 项研究中发现了令人难以相信的 59 种不同定义。我们之后选择了 4 种最常使用的定义,将它们应用到英国 2 个出生队列中的 >1000 名儿童(出生在相同的时间段中)身上。使用这些不同的定义导致被贴上 AD 标签儿童的数量(此病所谓的患病率)出现显著差异,以及基因和其他风险因素对于此病重要性评估的差异。...

artykuł

Different definitions of atopic dermatitis: impact on prevalence estimates and associated risk factors

T. Nakamura, S. Haider, S. Colicino, C.S. Murray, więcej

British Journal of Dermatology > 181 > 6 > 1272 - 1279

Background There is no objective test that can unequivocally confirm the diagnosis of atopic dermatitis (AD), and no uniform clinical definition. Objectives To investigate to what extent operational definitions of AD cause fluctuation in the prevalence estimates and the associated risk factors. Methods We first reviewed the operational definitions of AD used in the literature. We then tested...

artykuł

Prevention of cadmium‑induced neurotoxicity in rats by essential nutrients present in nuts

Z. Batool, F. Agha, S. Tabassum, T.S. Batool, więcej

Acta Neurobiologiae Experimentalis > 2019 > 79 > 2

Cadmium, a heavy metal with no physiological function in the human body, is considered a bio-hazard. It is also considered to be a potent neurotoxin. The primary sources of cadmium exposure are diet and cigarette smoke. It has been postulated that nutritional deficiencies can increase the risk of cadmium toxicity. Nuts provide essential nutrients which are necessary for the maintenance of brain health...

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Poly(2-oxazoline)s based biomaterials: A comprehensive and critical update

Thomas Lorson, Michael M. Lübtow, Erik Wegener, Malik S. Haider, więcej

Biomaterials > 2018 > 178 > C > 204-280

Poly(2-oxazoline)s have been investigated for decades as biomaterials. Pioneering early work suggested that hydrophilic poly(2-oxazoline)s are comparable to poly(ethylene glycol) regarding their potential as biomaterials, but the ready commercial availability of the latter has led to its meteoric rise to become the gold standard of hydrophilic synthetic biomaterials. In contrast, poly(2-oxazoline)s...

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Invasion of previously unreported dicot plant hosts by chickpea chlorotic dwarf virus in Pakistan

U. Hameed, M. Zia-Ur-Rehman, S. A. Ali, M. S. Haider, więcej

VirusDisease > 2019 > 30 > 1 > 95-100

Members of the genus, Mastrevirus (family, Gemniviridae) transmitted by leafhopper vectors infect monocotyledonous or dicotyledonous plants, and infection of agricultural crops results in reduced yield and quality. During 2012, a study was undertaken in the Punjab and Sindh Provinces in Pakistan to determine the identity of suspect geminiviruses associated with symptomatic cotton and vegetable plants...

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Phosphonium-based hydrophobic ionic liquids with fluorous anions for biodiesel production from waste cooking oil

Z. Ullah, M. A. Bustam, Z. Man, A. S. Khan, więcej

International Journal of Environmental Science and Technology > 2019 > 16 > 3 > 1269-1276

In this work, ionic liquids (ILs) containing the phosphonium cation and four different types of fluorous anions were synthesized and characterized with nuclear magnetic resonance spectroscopy, Fourier-transform infrared spectroscopy, elemental analyser (CHNS) and thermogravimetric techniques. The catalytic transesterification properties of the prepared ILs were investigated through the synthesis of...

artykuł

Temperature‐controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open‐label, proof‐of‐concept study

C. Gore, R. B. Gore, S. Fontanella, S. Haider, więcej

Clinical & Experimental Allergy > 48 > 5 > 594 - 603

Background Children with severe, persistent atopic eczema (AE) have limited treatment options, often requiring systemic immunosuppression. Objective To evaluate the effect of the temperature‐controlled laminar airflow (TLA) treatment in children/adolescents with severe AE. Methods We recruited 15 children aged 2‐16 years with long‐standing, severe AE and sensitization to ≥1 perennial inhalant...

artykuł

The Representation of Laji’een (Refugees) and Muhajireen (Migrants) in the Headlines of Jordan News Agency (PETRA)

Ahmad S. Haider, Saleh Olimy

International Journal for the Semiotics of Law - Revue internationale... > 2019 > 32 > 1 > 155-186

This paper explores the representation of Laji’een (Refugees) and Muhajireen (Migrants) in Jordan News Agency (PETRA). It uses the headlines of a 2.5 million word corpus of Arabic news articles in a time span of 5 years from 2012 to 2016. Chronologically analyzing the headlines shows a change in the representation of and attitudes towards refugees and migrants over the investigated period. The analysis...

artykuł

The Lady Cilento Children's Hospital and Heartkids Queensland: Cardiac Parent Support Group

S. Haider, A. Hyde, S. Vollbon, H. Cable, więcej

Heart, Lung and Circulation > 2018 > 27 > S2 > S428

artykuł

Grapevine immune signaling network in response to drought stress as revealed by transcriptomic analysis

Muhammad S. Haider, Mahantesh M. Kurjogi, M. Khalil-Ur-Rehman, Muhammad Fiaz, więcej

Plant Physiology and Biochemistry > 2017 > 121 > C > 187-195

Drought is a ubiquitous abiotic factor that severely impedes growth and development of horticulture crops. The challenge postured by global climate change is the evolution of drought-tolerant cultivars that could cope with concurrent stress. Hence, in this study, biochemical, physiological and transcriptome analysis were investigated in drought-treated grapevine leaves. The results revealed that photosynthetic...

artykuł

Neurosurgical “Squeeze Play”: Single Incision with Dual Ipsilateral Craniotomies Versus 2 Separate Approaches for Intracranial Aneurysm Treatment

Jan-Karl Burkhardt, Ali S. Haider, W. Caleb Rutledge, Doris Wang, więcej

World Neurosurgery > 2017 > 107 > C > 554-558

Patients with bilateral, multiple intracranial aneurysms (IA) can be safely treated using 1 lateral craniotomy. However, in patients with an additional pericallosal artery (PcaA) or distal anterior cerebral artery (ACA) aneurysm, an interhemispheric approach through a bifrontal craniotomy is needed. We investigated the safety of a single incision with dual ipsilateral craniotomies (“squeeze play”)...

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Positronium for Antihydrogen Production in the AEGIS Experiment

G. Consolati, S. Aghion, C. Amsler, G. Bonomi, więcej

Acta Physica Polonica A > 2017 > 132 > 5 > 1443-1449

The primary goal of the Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy (AEGIS) collaboration is to measure for the first time precisely the gravitational acceleration of antihydrogen, H̅, a fundamental issue of contemporary physics, using a beam of antiatoms. Indeed, although indirect arguments have been raised against a different acceleration of antimatter with respect to matter,...

artykuł

Hypoxia Gene Expression Signature Independently Predicts Prognosis for Prostate Cancer Patients

L. Yang, D. Roberts, M. Takhar, B. Bibby, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > S201

artykuł

Homeless women’s desire for and barriers to obtaining effective contraception

EK Corey, S Frazin, S Heywood, S Haider

Contraception > 2017 > 96 > 4 > 287

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