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Background and PurposeProteinase activated receptor 2 (PAR2) is a GPCR associated with inflammation, metabolism and disease. Clues to understanding how to block PAR2 signalling associated with disease without inhibiting PAR2 activation in normal physiology could be provided by studies of biased signalling.
Experimental ApproachPAR2 ligand GB88 was profiled for PAR2 agonist and antagonist properties...
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