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The widespread distribution of Paracetamol on the market is the reason why it would be preferable to use the fastest, simplest and least expensive method of preparing Paracetamol tablets, that is, through direct compression. Yet, it is well known that this drug exhibits bad flow properties, and poor compression ability which causes capping. Several manufacturers have prepared Paracetamol powders...
Part I described the production of sintered-like Paracetamol crystals. In this second part, the physicochemical and technological behaviour of these crystals is investigated. The wettability and dissolution properties are then studied. The crystals exhibit a polyhedric habit which induces good flow properties. The porous crystal structure, resulting from the arrangement of the microcrystallites...
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