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MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire...
To investigate the function of the α calcium-calmodulin-dependent kinase II (αCaMKII) inhibitory autophosphorylation at threonines 305 and/or 306, we generated knockin mice that express αCaMKII that cannot undergo inhibitory phosphorylation. In addition, we generated mice that express the inhibited form of αCaMKII, which resembles the persistently phosphorylated kinase at these sites. Our data demonstrate...
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