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While studies of human and bovine endothelial nitric oxide synthase (eNOS) demonstrate activation by Ca 2+ /calmodulin, recent progress demonstrates that eNOS phosphorylation can alter sensitivity to intracellular free calcium ([Ca 2+ ] i ). The sheep, however, is widely used as a model for cardiovascular adaptation to pregnancy and ovine uterine artery endothelial cell (UAEC)...
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