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Left ventricular (LV) diastolic dysfunction increases with age and is manifested by an early (E wave) to late (A wave) mitral inflow ratio of <1 in patients of age 65 yrs. To determine if mediastinal irradiation accelerates this age-related change, we recruited 226 patients who 1) had received mediastinal irradiation (>3500 rads) for treatment of Hodgkin's disease, and 2) had no history of...
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