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Regulation of intramitochondrial free calcium ([Ca 2+ ] m ) is critical in both physiological and pathological functioning of the heart. The full extent and importance of the role of [Ca 2+ ] m is becoming apparent as evidenced by the increasing interest and work in this area over the last two decades. However, controversies remain, such as the existence of beat-to-beat...
Mitochondrial Ca 2+ transport was initially considered important only in buffering of cytosolic Ca 2+ by acting as a “sink” under conditions of Ca 2+ overload. The main regulator of ATP production was considered to be the relative concentrations of high energy phosphates. However, work by Denton and McCormack in the 1970s and 1980s showed that free intramitochondrial Ca ...
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