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In our previous studies, the recombinant type II macrophage migration inhibitory factor homologue (rAs‐MIF) secreted from Anisakis simplex suppressed experimental inflammation mouse model through IL‐10 production and CD4+CD25+Foxp3+T‐cell recruitment. Also, TLR2 gene expression was significantly increased following rAs‐MIF treatment. To know the relation between TLR2 and amelioration mechanisms of...
Currently, little information is available regarding innate immunity to helminthic parasite infection. In this study, we isolated the excretory–secretory (ES) proteins from Anisakis simplex (sea mammal intestinal parasite) third stage larva. We determined that the levels of IL‐17 in the lung and lung draining lymph node of mice were increased sixfold as a result of intranasal treatment with ES proteins...
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