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Acupuncture (AP) is currently used worldwide to relieve pain. However, little is known about its mechanisms of action. We found that after spinal cord injury (SCI), AP inhibited the production of superoxide anion (O 2 ), which acted as a modulator for microglial activation, and the analgesic effect of AP was attributed to its anti-microglial activating action. Direct injection of a ROS scavenger...
Mutations in the APP gene lead to enhanced cleavage by the β- and γ-secretase, and increased Aβ formation, which are tightly associated with Alzheimer's disease (AD)-like neuropathological changes. To examine whether depositions of Aβ by APP mutations are increased, and if this is associated with potential pathogenic phenotypes, the APPsw was expressed in a transgenic line under the control of the...
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