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ShcA proteins mediate Erk1/Erk2 activation by integrins and epidermal growth factor (EGF), and are expressed as p46 ShcA , p52 ShcA , and p66 ShcA . Although p52 ShcA and p46 ShcA mediate Erk1/Erk2 activation, p66 ShcA antagonizes Erk activation. p66 ShcA is spatially regulated during lung development, leading us to hypothesize that integrin...
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