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Incidence and prevalence of Alzheimer's disease (AD) are higher in postmenopausal women than in age-matched men. Since at menopause the endocrine system and other biological paradigms undergo substantial changes, we thought to be of interest studying whether (and how) the balance between some biological parameters allegedly neuroprotective (e.g. related to estrogen, dehydroepiandrosterone and CD36...
CD36, a scavenger receptor of class B (SR-B), helps mediate microglial and macrophage response to β-amyloid fibrils (βA), and seems to play a key role in the proinflammatory events associated with Alzheimer disease (AD) in many tissues.Peripheral leukocytes express many molecules and multiple receptors which undergo the same regulatory mechanisms as those operative in the brain. Thus, these cells,...
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