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GPR91 is an orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for succinate, a citric acid cycle intermediate, in several tissues. In the heart, the role of succinate is unknown. We now report that rat ventricular cardiomyocytes express GPR91. We found that succinate, through GPR91, increases the amplitude and the rate of decline of global Ca 2+ transient,...
In the heart, cytosolic Ca 2+ signals are well-characterized events that participate in the activation of cell contraction. In contrast, nuclear Ca 2+ contribution to cardiomyocyte function remains elusive. Here, we examined functional consequences of buffering nuclear Ca 2+ in neonatal cardiomyocytes. We report that cardiomyocytes contain a nucleoplasmic reticulum, which expresses...
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