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Dried blood spot sampling technique has been a prevalent approach in therapeutic drug monitoring due to its numerous advantages over conventional blood or plasma sampling. But the effects of storage conditions, drying time in air and paper substrates on the stability and analysis sensitivity of therapeutic drugs are still lack. Herein we systematically investigated the effects of storage conditions...
A simple PID tuning method for dominant pole placement and phase margin specification is proposed in this paper. Time domain specifications as settling time and percentage overshoot are represented by a pair of dominant poles, which is combined with phase margin specification to achieve closed-loop stability and robustness. A graphical method is developed to determine PID settings to meet these specifications...
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