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Objective To explore the role of hypoxia-inducible factor-1α (HIF-1α) in formation of multidrug resistance (MDR) induced by microenvironment and to find a new and effective molecular target on preventing and reversing chemoresistance in hepatocellular carcinoma (HCC). Methods In HepG2 cells exposed to hypoxia, low glucose or transfected by plasmid pcDNA3/HBX, the expression of HIF-1α mRNA and...
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