Search results for: E. Magnus Ohman

Items from 1 to 20 out of 312 results

article

Timing of sedation and patient‐reported pain outcomes during cardiac catheterization: Results from the UNTAP‐intervention study

Anna Mall, T. Andrew Girton, Kevin Yardley, Meghan Ronn, more

Catheterization and Cardiovascular Interventions > 101 > 2 > 335 - 342

Background Invasive cardiac catheterization (CC) temporarily increases pain, discomfort, and anxiety. Procedural sedation is deployed to mitigate these symptoms, though practice varies. Research evaluating peri‐procedural patient‐reported outcomes is lacking. Methods and Results We randomized 175 patients undergoing CC to short interval ([SI] group, <6 min) or long interval ([LI] group, ≥6 min)...

article

Outcomes of bailout percutaneous ventricular assist device versus prophylactic strategy in patients undergoing nonemergent percutaneous coronary intervention

Brian P O'Neill, Cindy Grines, Jeffrey W. Moses, E. Magnus Ohman, more

Catheterization and Cardiovascular Interventions > 98 > 4 > E501 - E512

Objectives To compare in‐hospital outcomes of bailout support to prophylactic support with percutaneous ventricular assist devices (pVAD) for high‐risk nonemergent percutaneous coronary intervention (HRPCI). Background Prophylactic support with pVAD for a HRPCI is used in patients felt to be at risk for hemodynamic collapse during PCI. An alternative strategy of bailout pVAD support in the event...

article

Improvement in left ventricular function following higher‐risk percutaneous coronary intervention in patients with ischemic cardiomyopathy

Juan J. Russo, Megha Prasad, Darshan Doshi, Dimitrios Karmpaliotis, more

Catheterization and Cardiovascular Interventions > 96 > 4 > 764 - 770

Background Surgical revascularization is associated with improved ventricular function and clinical outcomes among patients with ischemic cardiomyopathy. There are less extensive data on changes in ventricular function among patients with ischemic cardiomyopathy undergoing percutaneous coronary intervention (PCI). Accordingly, we sought to assess the extent and predictors of change in left ventricular...

article

Understanding the patient experience of pain and discomfort during cardiac catheterization

Anna Mall, T. Andrew Girton, Kevin Yardley, Paige Rossman, more

Catheterization and Cardiovascular Interventions > 95 > 7 > E196 - E200

Objectives Patient centeredness is an essential component of high‐quality care, yet little is known regarding the patient experience during procedures performed in the cardiac catheterization lab. Background Available literature focuses on the safe delivery of sedation, but does not address patient‐reported satisfaction or comfort. Further delineation of how procedural factors impact the patient...

article

Technical consideration in acute myocardial infarction with cardiogenic shock: A review of antithrombotic and PCI therapies

Guillaume Marquis‐Gravel, Michel Zeitouni, Ajar Kochar, W. Schuyler Jones, more

Catheterization and Cardiovascular Interventions > 95 > 5 > 924 - 931

In this review, we report a contemporary appraisal of the available evidence focusing on adjunctive antithrombotic therapy and technical aspects of percutaneous coronary interventions (PCI) in patients with acute myocardial infarction and cardiogenic shock (AMICS). Only few randomized trials have been conducted to evaluate the optimal arterial access choice, antithrombotic therapy, stent type, or...

article

Maintenance of valvular integrity with Impella left heart support: Results from the multicenter PROTECT II randomized study

James A. Goldstein, Simon R. Dixon, Pamela S. Douglas, E. Magnus Ohman, more

Catheterization and Cardiovascular Interventions > 92 > 4 > 813 - 817

Background The Impella 2.5 axial flow pump, which is positioned across the aortic valve, is widely employed for hemodynamic support. The present study compared structural and functional integrity of the left heart valves in patients undergoing Impella vs intra‐aortic balloon pump in the randomized PROTECT II trial. Methods and Results Transthoracic echocardiograms were performed at baseline, 1...

article

Analysis of outcomes for 15,259 US patients with acute myocardial infarction cardiogenic shock (AMICS) supported with the Impella device

William W. O'Neill, Cindy Grines, Theodore Schreiber, Jeffrey Moses, more

American Heart Journal > 2018 > 202 > C > 33-38

The Impella percutaneous ventricular assist device (PVAD) rapidly deploys mechanical circulatory support (MCS) in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS). We present findings from a quality improvement (IQ) registry for US patients with AMICS who received Impella devices.From January 2009 to December 2016, 46,949 patients from 1010US hospitals were entered...

article

The cVAD registry for percutaneous temporary hemodynamic support: A prospective registry of Impella mechanical circulatory support use in high-risk PCI, cardiogenic shock, and decompensated heart failure

George W. Vetrovec, Mark Anderson, Theodore Schreiber, Jeffrey Popma, more

American Heart Journal > 2018 > 199 > C > 115-121

Management of patients requiring temporary, mechanical hemodynamic support during high- risk percutaneous coronary intervention (PCI) or in cardiogenic shock is rapidly evolving. With the availability of the Impella 2.5, CP, 5.0, LD, and RP percutaneous mechanical circulatory support devices, there is a need for continued surveillance of outcomes.Three factors underline the importance of a registry...

article

Predicting risk of cardiac events among ST-segment elevation myocardial infarction patients with conservatively managed non–infarct-related artery coronary artery disease: An analysis of the Duke Databank for Cardiovascular Disease

Sameer A. Hirji, Susanna R. Stevens, Linda K. Shaw, Erin C. Campbell, more

American Heart Journal > 2017 > 194 > C > 116-124

Recent randomized evidence has demonstrated benefit with complete revascularization during the index hospitalization for multivessel coronary artery disease ST-segment elevation myocardial infarction (STEMI) patients; however, this benefit likely depends on the risk of future major adverse cardiovascular events (MACE).Using data from Duke University Medical Center (2003-2012), we identified those...

article

Antithrombotic agents for secondary prevention after acute coronary syndromes: A systematic review and network meta-analysis

Alexander C Fanaroff, Vic Hasselblad, Matthew T Roe, Deepak L Bhatt, more

International Journal of Cardiology > 2017 > 241 > C > 87-96

Nine oral antithrombotic medications currently available in the United States and Europe have been studied in clinical trials for secondary prevention of cardiac events following acute coronary syndrome (ACS). Few combinations of these medications have been directly compared, and studies have used multiple different comparator regimens.We performed a systematic review and network meta-analysis of...

article

Revascularization Strategies and Outcomes in Elderly Patients With Multivessel Coronary Disease

J. Trevor Posenau, Daniel M. Wojdyla, Linda K. Shaw, Karen P. Alexander, more

The Annals of Thoracic Surgery > 2017 > 104 > 1 > 107-115

Balancing risks and benefits of revascularization in elderly patients with multivessel coronary artery disease (CAD) is challenging. The appropriate revascularization strategy for elderly patients with multivessel CAD is unclear.We used the Duke Databank for Cardiovascular Disease to identify patients aged 75 years or more who had multivessel disease and treatment with percutaneous coronary intervention...

article

Relationship between therapeutic effects on infarct size in acute myocardial infarction and therapeutic effects on 1-year outcomes: A patient-level analysis of randomized clinical trials

Harry P. Selker, James E. Udelson, Robin Ruthazer, Ralph B. D'Agostino, more

American Heart Journal > 2017 > 188 > C > 18-25

While infarct size in patients with ST-segment elevation myocardial infarction (STEMI) has been generally associated with long-term prognosis, whether a therapeutic effect on infarct size has a corresponding therapeutic effect on long-term outcomes is unknown.Using combined patient-level data from 10 randomized trials of primary percutaneous coronary intervention (PCI) for STEMI, we created multivariable...

article

Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome

Alice Wang, Lydia Coulter Kwee, Elizabeth Grass, Megan L. Neely, more

Atherosclerosis > 2017 > 261 > C > 19-25

Although circulating microRNA (miRNAs) have emerged as biomarkers predicting mortality in acute coronary syndrome (ACS), more data are needed to understand these mechanisms. Mapping miRNAs to high-risk traits may identify miRNAs involved in pathways conferring risk for poor outcome in ACS. We aim to investigate the relationship between circulating miRNAs and high-risk traits in non-ST-segment elevation...

article

Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus

Alexander C. Fanaroff, Stefan K. James, Giora Weisz, Kristi Prather, more

Journal of the American College of Cardiology > 2017 > 69 > 18 > 2304-2313

Chronic angina is more common in patients with diabetes mellitus (DM) with poor glucose control. Ranolazine both treats chronic angina and improves glucose control.This study sought to examine ranolazine’s antianginal effect in relation to glucose control.The authors performed a secondary analysis of the RIVER-PCI (Ranolazine in Patients with Incomplete Revascularization after Percutaneous Coronary...

article

Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial

E Magnus Ohman, Matthew T Roe, P Gabriel Steg, Stefan K James, more

The Lancet > 2017 > 389 > 10081 > 1799-1808

Dual antiplatelet therapy (DAPT), aspirin plus a P2Y12 inhibitor, is the standard antithrombotic treatment following acute coronary syndromes. The factor Xa inhibitor rivaroxaban reduced mortality and ischaemic events when added to DAPT, but caused increased bleeding. The safety of a dual pathway antithrombotic therapy approach combining low-dose rivaroxaban (in place of aspirin) with a P2Y12 inhibitor...

article

Potent P2Y12 Inhibitors in Men Versus Women

Emily S. Lau, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, more

Journal of the American College of Cardiology > 2017 > 69 > 12 > 1549-1559

Sex-specific differences in response to antiplatelet therapies have been described. Whether women and men derive comparable benefit from intensification of antiplatelet therapy remains uncertain.The study investigated the efficacy and safety of the potent P2Y₁₂ inhibitors in patients with coronary artery disease.A collaborative sex-specific meta-analysis was conducted of phase III or IV randomized...

article

Effect of Early Initiation of Mechanical Circulatory Support on Survival in Cardiogenic Shock

Mir B. Basir, Theodore L. Schreiber, Cindy L. Grines, Simon R. Dixon, more

The American Journal of Cardiology > 2017 > 119 > 6 > 845-851

The role and timing of percutaneous mechanical circulatory support (MCS) devices in the treatment of acute myocardial infarction complicated by cardiogenic shock (AMICS) are not well understood. We sought to evaluate patient characteristics and predictors of outcomes in patients presenting with AMICS supported with an axial flow percutaneous MCS device; 287 consecutive unselected patients enrolled...

article

Impact of Non-Infarct-Related Artery Disease on Infarct Size and Outcomes (from the CRISP-AMI Trial)

Rohan Shah, Robert M. Clare, Karen Chiswell, W. Schuyler Jones, more

The American Journal of Medicine > 2016 > 129 > 12 > 1307-1315

Non-infarct-related artery (non-IRA) disease is prevalent in patients with ST-segment elevation myocardial infarction (STEMI). We aimed to assess the impact of non-IRA disease on infarct size and clinical outcomes in patients with acute STEMI.The Counterpulsation to Reduce Infarct Size Pre-PCI Acute Myocardial Infarction (CRISP-AMI) trial randomized patients to intra-aortic balloon counterpulsation...

article

Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: Rationale and design of the TWILIGHT study

Usman Baber, George Dangas, David J. Cohen, C. Michael Gibson, more

American Heart Journal > 2016 > 182 > C > 125-134

Dual antiplatelet therapy (DAPT) is necessary to prevent thrombosis yet increases bleeding after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Antiplatelet monotherapy with a potent P2Y₁₂ receptor antagonist may reduce bleeding while maintaining anti thrombotic efficacy compared with conventional DAPT.TWILIGHT is a randomized, double-blind placebo-controlled trial evaluating...

article

Gender Differences in Associations Between Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention and Adverse Outcomes

Mikkel M. Schoos, Roxana Mehran, George D. Dangas, Jennifer Yu, more

The American Journal of Cardiology > 2016 > 118 > 11 > 1661-1668

Women are frequently reported to have increased morbidity after presentation with acute coronary syndromes and myocardial infarction; however, whether a greater thrombotic tendency contributes to gender differences in clinical outcomes of urgent percutaneous coronary intervention is unknown. Intraprocedural Thrombotic Events (IPTEs) are defined as new or increasing thrombus, abrupt vessel closure,...

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Search results for: E. Magnus Ohman

Timing of sedation and patient‐reported pain outcomes during cardiac catheterization: Results from the UNTAP‐intervention study

Outcomes of bailout percutaneous ventricular assist device versus prophylactic strategy in patients undergoing nonemergent percutaneous coronary intervention

Improvement in left ventricular function following higher‐risk percutaneous coronary intervention in patients with ischemic cardiomyopathy

Understanding the patient experience of pain and discomfort during cardiac catheterization

Technical consideration in acute myocardial infarction with cardiogenic shock: A review of antithrombotic and PCI therapies

Maintenance of valvular integrity with Impella left heart support: Results from the multicenter PROTECT II randomized study

Analysis of outcomes for 15,259 US patients with acute myocardial infarction cardiogenic shock (AMICS) supported with the Impella device

The cVAD registry for percutaneous temporary hemodynamic support: A prospective registry of Impella mechanical circulatory support use in high-risk PCI, cardiogenic shock, and decompensated heart failure

Predicting risk of cardiac events among ST-segment elevation myocardial infarction patients with conservatively managed non–infarct-related artery coronary artery disease: An analysis of the Duke Databank for Cardiovascular Disease

Antithrombotic agents for secondary prevention after acute coronary syndromes: A systematic review and network meta-analysis

Revascularization Strategies and Outcomes in Elderly Patients With Multivessel Coronary Disease

Relationship between therapeutic effects on infarct size in acute myocardial infarction and therapeutic effects on 1-year outcomes: A patient-level analysis of randomized clinical trials

Whole blood sequencing reveals circulating microRNA associations with high-risk traits in non-ST-segment elevation acute coronary syndrome

Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus

Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial

Potent P2Y12 Inhibitors in Men Versus Women

Effect of Early Initiation of Mechanical Circulatory Support on Survival in Cardiogenic Shock

Impact of Non-Infarct-Related Artery Disease on Infarct Size and Outcomes (from the CRISP-AMI Trial)

Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: Rationale and design of the TWILIGHT study

Gender Differences in Associations Between Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention and Adverse Outcomes

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