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There are multiple ways for cells to die, including necrosis, apoptosis, and autophagy. Apoptosis or programmed cell death or suicidal cell death is a physiological form of cell death, which is critical in cellular homeostasis. Apoptosis occurs in almost all cell types in the body and begins as early as eight cell embryo stage and continues throughout the lifespan of the organism, albeit at different...
Aging in humans is associated with progressing decline in T cell numbers and functions. In addition, there is an increased production of tumor necrosis factor-α (TNF-α) during human aging. TNF-α mediates both survival and cell death signals. TNF-α exerts its biological effects via TNFR-I and TNFR-II. Here we discuss signaling pathways induced by TNF-α and the effect of age on TNF-α-induced apoptosis...
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