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Kaempferol is a dietary flavonoid that can function as a selective estrogen receptor modulator (SERM). Estrogen‐related receptors alpha and gamma (ERRα and ERRγ) are orphan nuclear receptors that play important roles in mitochondrial biogenesis and cancer development. We have shown that kaempferol can functionally antagonize the activities of ERRs based on both response element reporter systems and...
Osteocalcin is one of the most abundant non‐collagenous proteins in bone that is commonly used as a preliminary biomarker in bone formation. Osteocalcin also regulates energy metabolism as a hormone. Estrogen‐related receptor alpha (ERRα) is primarily thought to regulate energy homeostasis through interacting with peroxisome proliferator‐activated receptor gamma coactivator‐1α (PGC‐1α). Intriguingly,...
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