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Background Metabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative radioligand for mGlu7 (binding constant KB = 30 nM), and evaluated its potential for imaging of mGlu7 via in vitro and in vivo techniques. Methods [11C]MMPIP was synthesized by...
The sources of carbon, which decrease the specific activity of [ 11 C]Methyl iodide [ 11 C]CH 3 I synthesized by the single pass I 2 method were, determined. Some organic solvents (acetone, CH 3 OH and THF etc.) and non-volatile oils (silicone oil and paraffin) could react with the I 2 vapor to yield the non-radioactive CH 3 I in the heated quartz...
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