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The effects of an acidic phospholipase A 2 (PLA 2 ) from Ophiophagus hannah venom on soleus muscle were studied by light and electron microscopic examination. Mice were injected intramuscularly with a dose of 8 mg/kg ofO. hannah venom PLA 2 and tissue samples were taken at 4, 6, 24, 48 hr, and 7 days after injection. The PLA 2 induced a progressive muscle degeneration...
An acidic phospholipase A 2 (OHV A-PLA 2 ), with cardiotoxic and myotoxic activities, was purified from the venom of Ophiophagus hannah (king cobra). The purity of OHV A-PLA 2 was ascertained by electrophoresis and by reverse-phase high-pressure liquid chromatography (RP-HPLC). OHV A-PLA 2 was analysed using an ionspray mass spectrometer and showed a molecular mass...
An acidic phospholipase A 2 (PLA 2 ) was isolated from the venom of Ophiophagus hannah (king cobra) by CM-Sephadex C-50 ion-exchange column chromatography and gel filtration on Sephadex G-50. The purified PLA 2 has a mol. wt of 13,000 and isoelectric point 5.7. It has been shown that the PLA 2 can cause a cardiotoxic action on rat heart (Huang et al., 1991, 1993)...
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