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Rectal cancer is often a curable disease when localized. Although adenocarcinoma of the rectum and adenocarcinoma of the more proximal colon have a similar histologic appearance, the natural history of rectal and colon cancer differs, due to epidemiological, anatomical and pathophysiological reasons. In high-risk populations the incidence of colon and rectal tumors is 2:1, with rectal cancer that...
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