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The xeroderma pigmentosum group F‐cross‐complementing rodent repair deficiency group 1 (XPF‐ERCC1) complex is a structure‐specific endonuclease involved in nucleotide excision repair (NER) and interstrand cross‐link (ICL) repair. Patients with XPF mutations may suffer from two forms of xeroderma pigmentosum (XP): XP‐F patients show mild photosensitivity and proneness to skin cancer but rarely show...
Two UV‐sensitive syndrome patients who have mild photosensitivity without detectable somatic abnormalities lack detectable Cockayne syndrome group B (CSB) protein because of a homozygous null mutation in the CSB gene. In contrast, mutant CSB proteins are produced in CS‐B patients with the severe somatic abnormalities of Cockayne syndrome and photosensitivity. It is known that the piggyBac transposable...
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