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The dichloromethane extract of Larrea tridentata (Creosote bush, Zygophyllaceae) showed activity against the protozoan pathogens Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani and Plasmodium falciparum (IC 50 2.8, 14.6, 5.2, 2.9μg/ml, cytotoxicity against L6 rat skeletal myoblasts: 25.4μg/ml).In search for potentially active constituents, nine lignans (three dibenzylbutanes,...
The CH 2 Cl 2 extract of aerial parts of Eupatorium perfoliatum L. exhibits antiprotozoal activity under in vitro conditions, especially against Plasmodium falciparum (IC 50 =2.7μg/ml). The search for active compounds yielded seven sesquiterpene lactones: Four structurally similar guaianolides, one dimeric guaianolide, and two germacranolides. The guaianolides differ in the...
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