The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
There is considerable evidence supporting the involvement of serotonin-2C (5-HT2C) receptors in the pathophysiology of depression. First, 5-HT2C receptors play an important role in the regulation of monoamine transmission. Second, abnormalities in expression and functioning of 5-HT2C receptors have been observed in depressed patients and in animal models of depression. Third, a large body of evidence...
Selective serotonin reuptake inhibitors are the most widely prescribed antidepressant drugs. However, they exhibit a slow onset of action, putatively due to the initial decrease in serotonin cell firing mediated via somato-dendritic autoreceptors. Interestingly, blockade of 5-HT 2C receptors significantly potentiates the effect of citalopram, a selective serotonin reuptake inhibitor, on serotonin...
Due to the interest in the antidepressant potential of nonpeptide corticotropin-releasing factor (CRF)1 receptor antagonists, the present investigation examined the antidepressant-like effects of the CRF1 receptor antagonist CP-154,526 on the exaggerated swim test immobility in the Flinders Sensitive Line (FSL) rat, a genetic animal model of depression. Chronic treatment with CP-154,526 (10 mg/kg;...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.