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Endogenous pregnane neurosteroids are allosteric modulators at γ-aminobutyric acid type-A (GABA A ) receptors at nanomolar concentrations. There is direct evidence for multiple distinct neurosteroid binding sites on GABA A receptors, dependent upon subunit composition and stoichiometry. This view is supported by the biphasic kinetics of various neuroactive steroids, enantioselectivity...
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