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We have synthesized alrestatin derivatives 1-11 possessing acyl benzenesulfonamide groups as surrogates for the carboxylic acid moeity of alrestatin. Most of the compounds were inactive as aldose reductase inhibitors compared to alrestatin, however, some of them demonstrated selectivity towards inhibition of rat kidney aldehyde reductase compared to rat lens aldose reductase suggesting that structural...
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