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TAS2R38 bitter taste receptors are seven-transmembrane (TM) domain G protein-coupled receptors (GPCRs) that can respond to bitter compounds such as Phenylthiocarbamide (PTC). We would like to understand the nature of the binding that is what aspect of the ligand interacting with the binding site leads to signal sent to the cortex. There are no direct determinations of the 3D structure of taste receptors;...
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