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Background
The role of postmastectomy radiotherapy (PMRT) in women with pT1‐T2N1 breast cancer is controversial. The authors developed a nomogram that was predictive for overall survival (OS) and identified patients who derived no benefit from PMRT.
Methods
The authors retrospectively evaluated 4869 patients with pT1‐T2N1 breast cancer who were treated with mastectomy between 2000 and 2014 in 11...
BACKGROUND:The high prevalence of v‐raf murine sarcoma viral oncogene homolog B1 (BRAF) and neuroblastoma v‐ras oncogene homolog (NRAS) mutations in melanoma provides a strong rationale to test the clinical efficacy of mitogen‐activated protein kinase kinase (MEK) inhibition in this disease. The authors hypothesized that the presence of BRAF or NRAS mutations would correlate with clinical benefit...
BACKGROUND:Mycosis fungoides (MF) and leukemic Sézary syndrome (SS) are the most common cutaneous T cell lymphomas (CTCL), but their etiology remains unknown. After patients were observed with hydrochlorothiazide (HCTZ)‐associated CTCL, HCTZ was examined as a putative chronic antigen in a cohort of prospectively staged patients.
METHODS:Demographic and drug exposure data was examined from 1443 confirmed...
BACKGROUND:Doxorubicin (Adriamycin) is effective in gastric cancer treatment, but with severe dose‐dependent toxicities. A novel prodrug of doxorubicin (Ac‐Phe‐Lys‐PABC‐ADM) is designed to deliver free doxorubicin relying on cathepsin B and reduce side effects. The authors examined the antitumor effect and toxicities of Ac‐Phe‐Lys‐PABC‐ADM against gastric cancer peritoneal carcinomatosis.
METHODS:SGC‐7901...
BACKGROUND:Nasal diffuse large B‐cell lymphoma (DLBCL) is rare. The objective of this study was to evaluate the clinical features and treatment outcomes of patients with nasal DLBCL.
METHODS:Twenty‐five patients were included in the study. All patients received combination chemotherapy with or without radiotherapy.
RESULTS:Patients with nasal DLBCL usually were older and were predominantly men with...
BACKGROUND:Enhancer of zeste homolog 2 (EZH2), a member of polycomb group proteins, is involved in the regulation of cell cycle progression and has been implicated in various human malignancies, including breast cancer, and also has been associated with aggressive tumor behavior. However, the clinical significance of EZH2 expression in inflammatory breast cancer (IBC), a rare but aggressive type of...
BACKGROUND:Pleomorphic liposarcoma (PLS) is a rare high‐grade sarcoma that has lipoblastic differentiation. In this study, the authors evaluated PLS natural history, patient outcomes, and commonly deregulated protein biomarkers.
METHODS:Medical records from patients (n = 155) who had PLS from 1993 to 2010 were reviewed. Univariate and multivariate analyses were conducted to identify independent prognosticators...
BACKGROUND:This study aimed to evaluate the failure patterns and clinical implications in patients with early stage nasal natural killer (NK)/T‐cell lymphoma treated with primary radiotherapy.
METHODS:Two‐hundred fourteen patients were included. There were 182 cases of stage I and 32 cases of stage II disease. Patients received radiotherapy alone (n = 96) or radiotherapy and chemotherapy (n = 118)...
BACKGROUND:One of the most common and deadly complications of melanoma is brain metastases. The outcomes of advanced melanoma patients who developed brain metastases were reviewed to identify significant prognostic factors for overall survival (OS).
METHODS:An institutional database of advanced melanoma patients enrolled on clinical trials in the Department of Melanoma Medical Oncology from 1986...
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