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Multilayer‐coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3‐labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer self‐assembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II‐GFP–green).
A new strategy to create biodegradable drug‐loaded coatings on microneedle patches, using a process known as layer‐by‐layer (LbL) self‐assembly, is reported on p. 4851 by Paula Hammond and coworkers. Water‐soluble polymers are adsorbed with oppositely‐charged drugs or drug‐carrying polymer particles in alternating layers, creating extremely thin coatings loaded with high levels of entrapped drugs...
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