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The enzymatic enantiodiscrimination of linear β‐haloalkanes is difficult because the simple structures of the substrates prevent directional interactions. Herein we describe two distinct molecular mechanisms for the enantiodiscrimination of the β‐haloalkane 2‐bromopentane by haloalkane dehalogenases. Highly enantioselective DbjA has an open, solvent‐accessible active site, whereas the engineered enzyme...
Mutationen von vier Resten entlang des Zugangstunnels verlängerten die Halbwertzeit eines Enzyms in 40 % Dimethylsulfoxid von Minuten zu Wochen und erhöhten die Schmelztemperatur um 19 °C. Proteinkristallographie und Moleküldynamik zeigen, dass die Packung der Tunnelreste entscheidend für die Proteinstabilität und die Zugänglichkeit des aktiven Zentrums für Cosolvens‐Moleküle (rote Punkte) ist.
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