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A breast cancer tumor suppressor gene has been localized to chromosome 16q24.3 by loss of heterozygosity (LOH) studies of breast tumor DNA. To identify candidate genes for this suppressor function, we have constructed a detailed physical map extending approximately 940 kb from the telomere of the long arm of chromosome 16 that encompasses the minimum LOH interval. This contig consists of a minimum...
Fanconi anemia (FA) is a genetically heterogenous disease involving at least five genes on the basis of complementation analysis (FAAtoFAE). TheFAAgene has been recently isolated by two independent approaches, positional and functional cloning. In the present study we describe the genomic structure of theFAAgene. The gene contains 43 exons spanning approximately 80 kb as determined by the alignment...
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