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Effects of Roux-en-Y gastric bypass (RYGB) on hypothalamic food intake regulation have not been investigated. The hypothalamic arcuate nucleus (ARC) and the magnocellular (m) and parvocellular (p) parts of the paraventricular nucleus (PVN) regulate hunger and satiety, and are under control of the orexigenic neuropeptide Y (NPY), and the anorexigenic α-melanocyte stimulating hormone (α-MSH) and serotonin...
Introduction: Obesity affects 30% of US population. For those patients refractory to conventional weight-loss therapy, Roux-en-Y gastric bypass operation (RYGB) is a proven method to induce sustained weigh-loss, although the mechanisms of weight loss remain speculative. We hypothesize that RYGB in a rat model induces a decrease in small bowel absorption, contributing to weight loss.Methods: Fourteen...
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