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Two-layered dissolving microneedles (DMs) containing the long-acting insulin analog, insulin glargine (IG), were prepared and a pharmacodynamic study was performed to evaluate the prolonged hypoglycemic effects of IG DMs in rats. DMs were approximately 487 ± 16 ßm (n = 8) in length and 293 ± 8 ßm (n = 8) in diameter at their base. The length of the insulin-loaded space was approximately 225 ± 21 ßm...
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