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Stimulation of secretion in exocrine cells is associated with the incorporation of up to 3 to 4 phosphates into the ribosomal protein S6. This occurs with secretagogues involving either cAMP or free calcium as second messenger. An analysis of the phosphorylation pattern of S6 from stimulated guineapig parotid glands reveals 3 phosphopeptides (termed A,B,C). The phosphopeptide pattern was identical...
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