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Background
A close association between hereditary alpha‐tryptasemia (HAT) and mast cell (MC) disorders has been previously reported. However, the relationship between HAT and the diagnostic subtypes and clinical features of MC disorders still remains to be established.
Objective
To determine the prevalence of HAT in healthy donors (HD) vs patients with different diagnostic subtypes of MC activation...
Background
Current diagnostic algorithms for systemic mastocytosis (SM) rely on the detection of KITD816V in blood to trigger subsequent bone marrow (BM) investigations.
Methods
Here, we correlated the KITD816V mutational status of paired blood and BM samples from 368 adults diagnosed with mast cell activation syndrome (MCAS) and mastocytosis and determined the potential utility of investigating...
Background
Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs−), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation‐associated compartments of bone...
Thaumetopoea pityocampa causes allergies and skin and ocular lesions. No commercial tools are currently available for the clinical diagnosis of this allergy. We aimed to develop an in vitro method for the diagnosis of this allergy to avoid patients undergoing in vivo tests with insect extracts. Recombinant Tha p 2 was produced and used in an ELISA validated with 15 allergic patients. Subsequently,...
BackgroundSkin testing‐guided elimination diet has proved unsuccessful for adult eosinophilic oesophagitis (EoE), whereas empiric six‐food elimination diet (SFED) achieves an efficacy of 70%.
ObjectiveTo compare the efficacy of food‐specific serum IgE‐targeted elimination diet (sIgE‐ED) and SFED.
MethodsProspective study in adult patients with EoE. Food‐specific serum IgE, skin prick test (SPT)...
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