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Background
Patients with late, ≥18 months postdiagnosis, isolated central nervous relapse (iCNS‐R) of B‐acute lymphoblastic leukemia (ALL) have excellent outcomes with chemotherapy plus cranial radiotherapy, with 5‐year overall survival (OS) approaching 80% in POG 9412. Subsequent relapse and radiation‐related morbidity remain the causes of treatment failure and long‐term sequelae. COG AALL02P2 aimed...
Background/Objectives
Anthracyclines are used in induction therapy of pediatric acute lymphoblastic leukemia (ALL) and are known to generate oxidative stress; whether this translates into enhanced antileukemic activity or hemolytic effects in patients with glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is unknown.
Design/Methods
Among 726 pediatric patients with newly diagnosed ALL treated...
Cancer cell resistance to chemotherapy may be mediated by defects in apoptotic pathways. A prior study showed that in vivo apoptosis of Acute Lymphoblastic Leukemia (ALL) blasts in response to chemotherapy could occur through diverse pathways including both p53-dependent and -independent mechanisms. In this study we investigated the apoptotic response in more detail by using a panel of ALL cell lines...
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