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Lung fibroblasts are crucial for the integrity of alveolar structure. Cigarette smoking, the major risk factor for chronic obstructive pulmonary disease, impairs the repair functions of lung fibroblasts.The study simultaneously assessed for the first time cell cycle, p53, p21, p38, ERK 1/2 and IL-8.Primary foetal lung fibroblasts (HFL-1) and primary lung fibroblasts from former (n=5) and current (n=5)...
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