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Neuropeptide S (NPS) is the endogenous ligand of a previously orphan receptor now named NPSR. In the brain NPS regulates several biological functions including anxiety, arousal, locomotion, food intake, learning and memory, pain and drug abuse. Mice lacking the NPSR gene (NPSR(−/−)) represent an useful tool to investigate the neurobiology of the NPS/NPSR system. NPSR(−/−) mice have been generated...
Neuropeptide S (NPS) regulates various biological functions by selectively activating the NPS receptor (NPSR). Recently, the NPSR ligand [ t Bu-d-Gly 5 ]NPS was generated and in vitro characterized as a pure antagonist at the mouse NPSR. In the present study the pharmacological profile of [ t Bu-d-Gly 5 ]NPS has been investigated. [ t Bu-d-Gly 5 ]NPS...
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