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We have isolated a novel cDNA (SEL1L) that shows sequence similarities to SEL-1, a gene identified as an extragenic suppressor of thelin-12hypomorphic mutant fromCaenorhabditis elegans(7, 8). SEL1L exhibits a tissue-specific pattern of expression: a single poly(A) + RNA species of 7.5 kb is abundantly expressed only in the pancreas of healthy individuals, whereas low to undetectable levels...
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