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P 53 protein expression was examined in 204 surgically removed colorectal adenocarcinomas by immunohistochemistry using frozen tissue sections and monoclonal antibody DO7. Nuclear staining of more than 5% of neoplastic cells was observed in 124 (60.8%) tumours, which were classified as p53 positive. p53 immunoreactivity was found to be unrelated to several clinical and pathological variables,...
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