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A gene encoding a ras protein with homology to the rheb family was cloned from Aspergillus fumigatus. Although conserved ras domains are present, the predicted RhbA protein sequence deviates from the ras consensus in a manner that is characteristic of rheb proteins. The invariant Gly–Gly in the first GTP-binding domain of ras proteins is replaced by Arg–Ser in RhbA, and a conserved Asp in the effector...
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