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Background & AimsActivating mutations of PIK3CA occur in various tumour types, including human hepatocellular carcinoma. The mechanisms whereby PIK3CA contributes to hepatocarcinogenesis remain poorly understood.
MethodsPIK3CA mutants H1047R or E545K were hydrodynamically transfected, either alone or in combination with NRasV12 or c‐Met genes, in the mouse liver.
ResultsOverexpression of H1047R...
De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in the pathogenesis of human hepatocellular carcinoma (HCC).We evaluated expression of enzymes that regulate lipogenesis in human normal liver tissues and HCC and surrounding, nontumor, liver tissues from patients using real-time reverse transcription polymerase chain reaction, immunoblotting,...
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