Search results for: Benoit H. Mulsant

Items from 1 to 20 out of 181 results

article

Alcohol and substance use in older adults with treatment‐resistant depression

Maytinee Srifuengfung, Eric J. Lenze, Steven P. Roose, Patrick J. Brown, more

International Journal of Geriatric Psychiatry > 39 > 6 > n/a - n/a

Introduction Alcohol and substance use are increasing in older adults, many of whom have depression, and treatment in this context may be more hazardous. We assessed alcohol and other substance use patterns in older adults with treatment‐resistant depression (TRD). We examined patient characteristics associated with higher alcohol consumption and examined the moderating effect of alcohol on the association...

article

Challenges in defining treatment‐resistant mania in adults: A systematic review

Christina Gonzalez‐Torres, Benoit H. Mulsant, M. Ishrat Husain, Martin Alda, more

Bipolar Disorders > 26 > 1 > 7 - 21

Objectives To review the definitions of treatment‐resistant mania (TRM) in the literature and propose criteria for an operationalized definition. Methods A systematic search of five databases (MEDLINE, EMBASE, PsychInfo, Cochrane Central, and CINAHL) and data extraction of eligible articles. Results In total, 47 articles addressing the concept of TRM were included, comprising 16 case reports,...

article

Support to caregivers who have received genetic information about neurodevelopmental and psychiatric vulnerability in their young children: A narrative review

Polina Perlman, Jacob Vorstman, Ny Hoang, Jane Summers, more

Clinical Genetics > 104 > 2 > 163 - 173

Diagnosis of pathogenic genetic variants associated with neurodevelopmental and psychiatric disorders (NPDs) is increasingly made early in life. This narrative review focuses on the need for, and provision of, psychological supports following genetic diagnosis. We conducted a literature search of publications on how caregivers are informed about the NPD vulnerability associated with genetic variants,...

article

Change in patient‐centered outcomes of psychological well‐being, sleep, and suicidality following treatment with intravenous ketamine for late‐life treatment‐resistant depression

Benjamin Vanderschelden, Marie Anne Gebara, Hanadi Ajam Oughli, Meryl A. Butters, more

International Journal of Geriatric Psychiatry > 38 > 7 > n/a - n/a

Objective To examine whether psychological well‐being, sleep, and suicidality improved with treatment with intravenous (IV) ketamine for late‐life treatment‐resistant depression (TRD). Methods This is an analysis of secondary outcomes in an open‐label late‐life TRD study examining the safety, tolerability, and feasibility of IV ketamine infusions. In the acute phase, participants (N = 25) aged...

article

Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project

Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, more

Bipolar Disorders > 25 > 1 > 43 - 55

Objectives The distinction between bipolar I disorder (BD‐I) and bipolar II disorder (BD‐II) has been a topic of long‐lasting debate. This study examined differences between BD‐I and BD‐II in a large, global sample of OABD, focusing on general functioning, cognition and somatic burden as these domains are often affected in OABD. Methods Cross‐sectional analyses were conducted with data from the...

article

Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults

Paola Lavin, Gabriella Buck, Osvaldo P. Almeida, Chien‐Lin Su, more

International Journal of Geriatric Psychiatry > 37 > 12 > n/a - n/a

Objectives Late‐onset bipolar disorder (LOBD) represents a significant subgroup of bipolar disorder (BD). However, knowledge for this group is mostly extrapolated from small studies in subjects with early/mixed age of illness onset. In this global sample of older adults with BD (OABD: ≥50 years old) we aim to characterize the sociodemographic and clinical presentation of LOBD (≥40 years at BD onset)...

article

Technology‐enabled collaborative care for youth with early psychosis: Results of a feasibility study to improve physical health behaviours

Osnat Melamed, Aristotle Voineskos, Lenka Vojtila, Iqra Ashfaq, more

Early Intervention in Psychiatry > 16 > 10 > 1143 - 1151

Aim Psychotic disorders are associated with excess morbidity and premature mortality. Contributing factors include tobacco smoking, low physical activity, and poor nutrition. This study tested a Technology‐Enabled Collaborative Care model to improve health behaviours among youth with early psychosis. Methods A feasibility study among youth (ages 16–29) with early psychosis in Ontario, Canada. Participants...

article

MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients

Mohamed Ismail, Thomas Straubinger, Hiroyuki Uchida, Ariel Graff‐Guerrero, more

British Journal of Clinical Pharmacology > 88 > 7 > 3341 - 3350

Aims Develop a robust and user‐friendly software tool for the prediction of dopamine D₂ receptor occupancy (RO) in patients with schizophrenia treated with either olanzapine or risperidone, in order to facilitate clinician exploration of the impact of treatment strategies on RO using sparse plasma concentration measurements. Methods Previously developed population pharmacokinetic models for olanzapine...

article

Effect of high frequency versus theta‐burst repetitive transcranial magnetic stimulation on suicidality in patients with treatment‐resistant depression

Shobha Mehta, Jonathan Downar, Benoit H. Mulsant, Daphne Voineskos, more

Acta Psychiatrica Scandinavica > 145 > 5 > 529 - 538

Objective To investigate the effect of 10 Hz repetitive transcranial magnetic stimulation (rTMS) and intermittent theta‐burst stimulation (iTBS) on suicidality in patients with treatment‐resistant depression (TRD). Methods We used data from a three‐site randomized clinical trial comparing 10 Hz rTMS and iTBS applied to the left dorsolateral prefrontal cortex (DLPFC) in patients with TRD. We compared...

article

“What else can we do?”—Provider perspectives on treatment‐resistant depression in late life

Megan E. Hamm, Jordan F. Karp, Emily Lenard, Alicia Dawdani, more

Journal of the American Geriatrics Society > 70 > 4 > 1190 - 1197

Background Treatment‐resistant depression in late‐life (TRLLD) is common. Perspectives of primary care providers (PCPs) and psychiatrists treating TRLLD could give insights into the challenges and potential solutions for managing this condition. Methods To identify perspectives of providers who treat TRLLD, we conducted a qualitative descriptive study using semi‐structured interviews with providers...

article

Efficacy and acceptability of pharmacotherapy for comorbid anxiety symptoms in bipolar disorder: A systematic review and meta‐analysis

Clare Cullen, Nils Kappelmann, Madeha Umer, Ali Abdolizadeh, more

Bipolar Disorders > 23 > 8 > 754 - 766

Objective Anxiety symptoms are highly prevalent among individuals with bipolar disorder (BD) but there is little guidance on pharmacotherapy for these symptoms. The objective of this systematic review and meta‐analysis was to evaluate the available evidence for pharmacotherapy of comorbid anxiety symptoms in BD. Methods Completed randomized clinical trials (RCTs) of medications for BD published...

article

Technology‐enabled collaborative care for youth with early psychosis: A protocol for a feasibility study to improve physical health behaviours

Peter Selby, Lenka Vojtila, Iqra Ashfaq, Rosa Dragonetti, more

Early Intervention in Psychiatry > 15 > 4 > 828 - 836

Aim Individuals with psychotic disorders have poorer health outcomes and die earlier due to cardiovascular diseases when compared to healthy populations. Contributing factors include low levels of physical activity, poor nutrition and tobacco smoking. Currently, patients navigate a fragmented health‐care system to seek physical and mental health services, often without access to evidence‐based health...

article

A double‐blind, randomized, placebo‐controlled pilot trial of atorvastatin for nephrogenic diabetes insipidus in lithium users

Jocelyn Fotso Soh, Serge Beaulieu, Francesco Trepiccione, Outi Linnaranta, more

Bipolar Disorders > 23 > 1 > 66 - 75

Objective Lithium remains an important treatment for mood disorders but is associated with kidney disease. Nephrogenic diabetes insipidus (NDI) is associated with up to 3‐fold risk of incident chronic kidney disease among lithium users. There are limited randomized controlled trials (RCT) for treatments of lithium‐induced NDI, and existing therapies can be poorly tolerated. Therefore, novel treatments...

article

A pilot study of magnetic seizure therapy for treatment‐resistant obsessive–compulsive disorder

Victor M. Tang, Daniel M. Blumberger, Cory R. Weissman, Julia Dimitrova, more

Depression and Anxiety > 38 > 2 > 161 - 171

Background There is growing interest in the potential of neuromodulation options in treatment‐resistant obsessive–compulsive disorder (OCD). Magnetic seizure therapy (MST), is a new treatment intervention in which generalized seizures are induced with transcranial magnetic stimulation. We conducted a pilot study to assess the efficacy and cognitive effects of MST in patients with treatment‐resistant...

article

Effects of bilateral transcranial direct current stimulation on working memory and global cognition in older patients with remitted major depression: A pilot randomized clinical trial

Sanjeev Kumar, Judah Batist, Zaid Ghazala, Reza M. Zomorrodi, more

International Journal of Geriatric Psychiatry > 35 > 10 > 1233 - 1242

Objectives To assess the effects of a 10‐day course of bilateral anodal transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) on working memory and global cognition in elderly participants with remitted major depressive disorder at 14 days (primary outcome) and 90 days (secondary outcome) post intervention. Design Randomized double blind controlled trial (clinicaltrials...

article

Functional Competence and Cognition in Individuals With Amnestic Mild Cognitive Impairment

Pallavi Dham, Kathleen S. Bingham, Christopher R. Bowie, Meryl A. Butters, more

Journal of the American Geriatrics Society > 68 > 8 > 1787 - 1795

OBJECTIVE The objective of this study is to characterize functional competence (measure of assistance needed for independence) on Performance Assessment of Self‐Care Skills (PASS) Cognitively Mediated Instrumental Activities of Daily Living (C‐IADL), in individuals with amnestic mild cognitive impairment (aMCI). It aims to determine: (1) the association of functional competence on PASS C‐IADL tasks...

article

Action at a Distance: Geriatric Research during a Pandemic

Ginger E. Nicol, Jay F. Piccirillo, Benoit H. Mulsant, Eric J. Lenze

Journal of the American Geriatrics Society > 68 > 5 > 922 - 925

BACKGROUND “Action at a distance” may be the new norm for clinical researchers in the context of the COVID‐19 pandemic that may require social distancing for the next 18 months. We must minimize face‐to‐face contact with vulnerable populations. But we must also persist, adapt, and help our older patients and study participants during the pandemic. METHODS Clinical researchers have an obligation...

article

Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment

Yasmina M. Saade, Ginger Nicol, Eric J. Lenze, J. Philip Miller, more

Depression and Anxiety > 36 > 12 > 1125 - 1134

Objective The purpose of this study was to examine the influence of comorbid anxiety symptoms on antidepressant treatment remission in older adults with major depressive disorder (MDD). Method In this multisite clinical trial, 468 older adults aged 60 years or older with MDD received open‐label protocolized treatment with venlafaxine extended release (ER) titrated to a maximum of 300 mg daily....

article

The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD) project: Understanding older‐age bipolar disorder by combining multiple datasets

Martha Sajatovic, Lisa T. Eyler, Soham Rej, Osvaldo P. Almeida, more

Bipolar Disorders > 21 > 7 > 642 - 649

Objective There is a dearth of research about the aging process among individuals with bipolar disorder (BD). One potential strategy to overcome the challenge of interpreting findings from existing limited older‐age bipolar disorder (OABD) research studies is to pool or integrate data, taking advantage of potential overlap or similarities in assessment methods and harmonizing or cross‐walking measurements...

article

Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment

Eric E. Brown, Neda Rashidi‐Ranjbar, Fernando Caravaggio, Philip Gerretsen, more

Journal of Neuroimaging > 29 > 6 > 721 - 729

BACKGROUND AND PURPOSE Amyloid deposition, tau neurofibrillary tangles, and cerebrovascular dysfunction are important pathophysiologic features in Alzheimer's disease. Pittsburgh compound B ([¹¹C]‐PIB) is a positron emission tomography (PET) radiotracer used to quantify amyloid deposition in vivo. In addition, certain models of [¹¹C]‐PIB delivery reflect cerebral blood flow rather than amyloid plaques...

Publication date

Last year (2)
Last 3 years (11)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

INFONA - science communication portal

Search results for: Benoit H. Mulsant

Alcohol and substance use in older adults with treatment‐resistant depression

Challenges in defining treatment‐resistant mania in adults: A systematic review

Support to caregivers who have received genetic information about neurodevelopmental and psychiatric vulnerability in their young children: A narrative review

Change in patient‐centered outcomes of psychological well‐being, sleep, and suicidality following treatment with intravenous ketamine for late‐life treatment‐resistant depression

Bipolar I and bipolar II subtypes in older age: Results from the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE‐BD) project

Clinical correlates of late‐onset versus early‐onset bipolar disorder in a global sample of older adults

Technology‐enabled collaborative care for youth with early psychosis: Results of a feasibility study to improve physical health behaviours

MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients

Effect of high frequency versus theta‐burst repetitive transcranial magnetic stimulation on suicidality in patients with treatment‐resistant depression

“What else can we do?”—Provider perspectives on treatment‐resistant depression in late life

Efficacy and acceptability of pharmacotherapy for comorbid anxiety symptoms in bipolar disorder: A systematic review and meta‐analysis

Technology‐enabled collaborative care for youth with early psychosis: A protocol for a feasibility study to improve physical health behaviours

A double‐blind, randomized, placebo‐controlled pilot trial of atorvastatin for nephrogenic diabetes insipidus in lithium users

A pilot study of magnetic seizure therapy for treatment‐resistant obsessive–compulsive disorder

Effects of bilateral transcranial direct current stimulation on working memory and global cognition in older patients with remitted major depression: A pilot randomized clinical trial

Functional Competence and Cognition in Individuals With Amnestic Mild Cognitive Impairment

Action at a Distance: Geriatric Research during a Pandemic

Comorbid anxiety in late‐life depression: Relationship with remission and suicidal ideation on venlafaxine treatment

The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE‐BD) project: Understanding older‐age bipolar disorder by combining multiple datasets

Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment

Filter options

Publication date

Content availability

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Benoit H. Mulsant

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options