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The basic region of c-Myc and other basic helix–loop–helix (b-HLH)-containing proteins bind to the palindromic DNA sequences CANNTG. For the myogenic factor MyoD, a member of the b-HLH family, mutation of several basic region residues abrogates muscle differentiation, but not DNA binding. One of the amino acid positions displaying this behavior in MyoD aligns with a highly conserved asparagine in...
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