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Chronic obstructive pulmonary disease (COPD) is a disorder of the lung parenchyma characterised by varying combinations of chronic bronchitis and emphysema [1]. Only recently we have realized that COPD is also associated with significant abnormalities outside of the lungs, the so-called systemic features of COPD. These systemic features are clinically relevant because they contribute to jeopardize...
Background Cardiovascular diseases are frequent in patients with obstructive sleep apnea (OSAS). There is evidence that the day–night pattern of myocardial infarction and sudden cardiac death observed in the general population is altered in patients with OSAS. This study investigates potential abnormalities in the circadian profiles of platelet activity in OSAS. Methods We studied 37 patients with...
Background Obstructive sleep apnea syndrome (OSAS) is a complex disease with a strong genetic basis. One of the primary molecular domains affected by OSAS is sympathetic activity. Neuropeptide S (NPS) plays an important role in the regulation of the sleep–wakefulness cycle, anxiety states, and daytime sleepiness. It is important to study neuropeptides related to sympathetic activity regulation and...
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