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To study effects of intrasphincteric injectionsof botulinum toxin on the sphincter of Oddi cyclicmotility and responses to motilin and cholecystokinin,four conscious dogs with duodenal cannula underwent manometry of the common bile duct, sphincter ofOddi, and duodenum. After baseline recording, each doghad intrasphincteric injections of saline or botulinumtoxin. The injections of saline had no effect,...
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