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Activation of metabotropic glutamate receptors (mGluRs) can potentiate the cAMP response elicited by activation of β-adrenergic receptors (βARs) in the hippocampus. We have shown that co-activation of mGluRs and βARs induces both an acute depression of excitatory synaptic transmission and a long-lasting excitation of CA1 pyramidal cells. However, these studies were performed using a non-selective...
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